Skip to Content

10 Most Poisonous Animals in the World

Welcome to the top 10 Most Poisonous Animals in the World!

Don’t expect a long list of snakes and spiders. The difference between poisonous and venomous must first be clarified before getting into the animals that make up the top 10 most poisonous animals in the world.

Poison is a toxin that gets into the body by inhaling, ingesting, or absorbing through the skin. At the same time, venom is a toxin injected into a body by bites, stingers, or fangs.

red frog

Tough to say which we are more likely to come across when out in the wild. To discover which animals contribute to being the most poisonous, continue reading below!

This list is by no means exhaustive, but getting into the list of the top 10 most poisonous animals in the world is a surprising start, so here we go:

#1 Pufferfish

top 10 most poisonous animals in the world: pufferfish

You might recognize this fish as Mr. Sikes from Shark Tale. But what the animation film didn’t teach us was that these fish are highly poisonous.

Also known as blowfish, these fish are a delicacy in Japan. However, the liver, kidneys, and spikes of pufferfish are incredibly poisonous. The toxin these fish produce is tetrodotoxin, which is 1,200 times more deadly than cyanide. One pufferfish is enough to kill 30 human adults.

Without a known antidote, they make number one on the top 10 most poisonous animals in the world. These fish, when threatened, can puff up to two or three times their size by ingesting vast amounts of air and water.

#2 Striated Surgeonfish

top 10 most poisonous animals in the world: striated surgeonfish

Striated surgeonfish are one of the few known herbivores that are poisonous. What makes striated surgeonfish poisonous is what they eat.

Number two on the top 10 most poisonous animals in the world list, this fish eats algae which means it occasionally ingests dinoflagellates. Dinoflagellates, when concentrated, produce a toxin known to cause neurological damage to humans and can be fatal.

The most common surgeonfish is the Blue Tang, which is non-toxic, and also eats algae but cannot digest dinoflagellates unlike the striated surgeonfish that can concentrate dinoflagellates to produce a toxin.

#3 Rough-skinned Newt

top 10 most poisonous animals in the world: rough-skinned newt

This North American semi-aquatic amphibian reaches a mere 8 inches (22 centimeters), but don’t pick this guy up for a closer look.

Newts produce tetrodotoxin that is stored in their skins and, when ingested, is particularly poisonous. The number three on the world’s top 10 most poisonous animals uses this toxin to defend itself from predators.

But, before releasing the toxin, it gives off a warning scent to deter its predators. Cases of poisoning have been reported from the handling of the newt with human hands.

#4 Comb Star

top 10 most poisonous animals in the world: comb star

Comb stars are the most widespread type of sea star in the Indo-Pacific region. Like pufferfish and rough-skinned newts, comb stars poison using tetrodotoxin.

The echinoderm stores the toxin in its spikes or spines. Comb stars are well camouflaged as they bury themselves under a thin layer of silty sea sand. Comb stars are referred to as sea stars instead of starfish as they are not fish at all.

Sea stars have no brain or blood but do have nervous systems to regulate nutrient flows. Sea stars can also regenerate lost limbs, although it takes a long time.

#5 Spanish Fly

top 10 most poisonous animals in the world: spanish fly

The Spanish fly is not a fly but rather a beetle found across Europe and Asia. These emerald green beetles are part of the blister beetle family because the toxin they produce called cantharidin is a blistering-causing agent.

Cantharidin is known to humans since antiquity. Apothecaries sourced the toxin from Spanish fly dung by royalty and desolate lovers as an aphrodisiac.

But when used in the wrong dosage or prepared incorrectly could lead to the formation of nasty boils. These beetles grow only to a maximum of 0.79 inches (20mm) long.

#6 Poison Dart Frog

top 10 most poisonous animals in the world: poison dart frog

The only animal on the list of top 10 most poisonous animals in the world to boast the word ‘poison’ in its name, the poison dart frog is a group of brightly colored and wildly patterned frogs.

These aposematic Central and South American amphibians are also known to produce 28 different alkaloid poisons, accumulating through their diets of ants, termites, and centipedes. These frogs grow roughly the size of a human thumb. Poison dart frogs are unsafe to handle as they store their poison in their skin.

The origin of their name is due to a practice wherein blow dart tips were dipped into the toxic secretions of these frogs and used for hunting. However, due to increased deforestation, these frogs are becoming increasingly endangered.

#7 Cane Toad

top 10 most poisonous animals in the world: cane toad

The cane toad, a marine toad, is found ironically on terrestrial land in South and Central America. Number seven, on the top 10 most poisonous animals in the world list, stores a type of poison in its glands called bufotoxins, making it particularly poisonous when ingested.

The toxins cane toads produce are named after their genus bufo. The need for toxic skin is derived from an a-symbiotic relationship between the Asian tiger snake and the cane toads.

#8 Hawksbill Sea Turtle

top 10 most poisonous animals in the world: hawksbill sea turtle

Unlike the cane toad, which produces poison, the hawksbill sea turtle is poisonous because of what it eats: jellyfish and sponges. This critically endangered turtle‘s flesh and fat absorb the toxins from the sponges and jellyfish it eats, making them poisonous when ingested but leaving the turtle unharmed.

Despite being critically endangered, hawksbill sea turtles are still hunted for their shells even though their flesh is poisonous. These turtles are so named due to the resemblance of their heads to birds’ beaks.

#9 Hooded Pitohui

top 10 most poisonous animals in the world: hooded pitohui

The penultimate top 10 most poisonous animals in the world is a hooded Pitohui of the Pitohui genus found in New Guinea. The bird stores a toxin known as batrachotoxin in its feathers and skin.

The toxin is derived from the diet of the bird. Batrachotoxin is one of the most toxic compounds by weight. Known to cause numbness and burning when human hands handle the bird. Toxicity in birds is unusual, making the hooded Pitohui an exceptionally unusual poisonous animal.

#10 Asian Tiger Snake

top 10 most poisonous animals in the world: asian tiger snake

She is commonly known as a tiger keelback. This Asian and southeast Asian tiger snake sequesters its toxin from number seven on this list of the world’s top 10 most poisonous animals: the cane toad.

The snake’s diet consists of cane toads. Hence these snakes have glands along their necks filled with the bufotoxin from the toad to use against its predators. Making this snake the only snake to be both poisonous and venomous.

Due to its known behavioral change based on environmental temperature, this snake can choose when to be venomous and poisonous. That is why this snake seals off the world’s top 10 most poisonous animals.

Mechanism Of Action

purple snake

Tetrodotoxin and bufotoxin are the two most commonly referred to toxins in this article. The former interfere with transmitting signals from nerves to muscles by blocking the salt channels in the human body.

Bufotoxin may affect the heart, blood pressure, and breathing and can cause paralysis, salivation, twitching, and vomiting in humans. Extended exposure may lead to death.


Rule number one of being in the wild is never touching or picking anything. If you stick to this rule you will most likely avoid contact with most of the animals on this list. Admire them from afar, and count yourself lucky to see them in their natural habitats.

Furthermore, do not be a participant to the trade and sale of these precious creatures as trinkets and mere items. Be activists and voices for them and their habitats. Only with our care and conservation can this beautiful planet and its inhabitants live peacefully and fairly.

If you accidentally come into contact with one of these animals on this list, immediately get to an emergency center or hospital for treatment.

Summary of the Most Poisonous Animals in the World

Whether this list surprised you or scared you, identify and recognize some of the animals on this list when you’re out in the wild.

The most important takeaway is that these animals have developed a tolerance to the poisons they exude and eat. The after-effect is that we are poisoned when humans ingest any of these animals. Relatively best to leave animals in peace.

The golden rule when out in nature is to never touch anything, especially in the sea, as these are sensitive biomes. Respect that; you’re unlikely to be poisoned by one of the above!

If you enjoyed reading about the animals above, check out the top 10 fastest animals in the world and top 10 most endangered animals in the world next!